Genome-wide association studies of cancer.

Published

Journal Article

Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies. Increased knowledge about the human genome and advances in genotyping technology have made possible genome-wide association studies (GWAS) of human diseases. These studies have identified many important regions of genetic variation associated with an increased risk for human traits and diseases including cancer. Understanding the principles, major findings, and limitations of GWAS is becoming increasingly important for oncologists as dissemination of genomic risk tests directly to consumers is already occurring through commercial companies. GWAS have contributed to our understanding of the genetic basis of cancer and will shed light on biologic pathways and possible new strategies for targeted prevention. To date, however, the clinical utility of GWAS-derived risk markers remains limited.

Full Text

Duke Authors

Cited Authors

  • Stadler, ZK; Thom, P; Robson, ME; Weitzel, JN; Kauff, ND; Hurley, KE; Devlin, V; Gold, B; Klein, RJ; Offit, K

Published Date

  • September 2010

Published In

Volume / Issue

  • 28 / 27

Start / End Page

  • 4255 - 4267

PubMed ID

  • 20585100

Pubmed Central ID

  • 20585100

Electronic International Standard Serial Number (EISSN)

  • 1527-7755

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/JCO.2009.25.7816

Language

  • eng