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Survival in epithelial ovarian cancer: a multivariate analysis incorporating BRCA mutation status and platinum sensitivity.

Publication ,  Journal Article
Gallagher, DJ; Konner, JA; Bell-McGuinn, KM; Bhatia, J; Sabbatini, P; Aghajanian, CA; Offit, K; Barakat, RR; Spriggs, DR; Kauff, ND
Published in: Annals of oncology : official journal of the European Society for Medical Oncology
May 2011

Patients with BRCA-associated ovarian cancer (OC) have a survival advantage over those with sporadic OC. To further explore this, we examined the impact of prognostic factors on disease-free survival (DFS) and overall survival (OS) in patients with known BRCA mutation status.We reviewed stage III-IV OC patients treated at our institution between 1 December 1996 and 30 September 2006 and also tested on protocol for BRCA mutations. Impact on DFS and OS was determined by Kaplan-Meier analysis and a Cox proportional hazards model.Of the 110 patients, 36 had deleterious BRCA mutations [BRCA (+)] and 74 were BRCA wild type [BRCA(-)]. Thirty-one of 36 (86%) BRCA (+) and 60 of 74 (81%) BRCA (-) patients were platinum sensitive (P = 0.60). Median OS was longer for BRCA (+) patients (not reached versus 67.8 months; P = 0.02), but DFS was similar (26.9 versus 24.0, P = 0.3). On multivariate analysis, OS correlated with primary platinum sensitivity [HR = 0.15; 95% CI (confidence interval) 0.06-0.34] and BRCA (+) mutation status (HR = 0.33; 95% CI 0.12-0.86).BRCA mutation status predicted OS independent of primary platinum sensitivity, suggesting that underlying tumor biology contributes to disease outcome and may be worthy of consideration in future clinical trial design.

Published In

Annals of oncology : official journal of the European Society for Medical Oncology

DOI

EISSN

1569-8041

ISSN

0923-7534

Publication Date

May 2011

Volume

22

Issue

5

Start / End Page

1127 / 1132

Related Subject Headings

  • Platinum
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
  • Multivariate Analysis
  • Middle Aged
  • Kaplan-Meier Estimate
  • INDEL Mutation
  • Humans
 

Citation

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Gallagher, D. J., Konner, J. A., Bell-McGuinn, K. M., Bhatia, J., Sabbatini, P., Aghajanian, C. A., … Kauff, N. D. (2011). Survival in epithelial ovarian cancer: a multivariate analysis incorporating BRCA mutation status and platinum sensitivity. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 22(5), 1127–1132. https://doi.org/10.1093/annonc/mdq577
Gallagher, D. J., J. A. Konner, K. M. Bell-McGuinn, J. Bhatia, P. Sabbatini, C. A. Aghajanian, K. Offit, R. R. Barakat, D. R. Spriggs, and N. D. Kauff. “Survival in epithelial ovarian cancer: a multivariate analysis incorporating BRCA mutation status and platinum sensitivity.Annals of Oncology : Official Journal of the European Society for Medical Oncology 22, no. 5 (May 2011): 1127–32. https://doi.org/10.1093/annonc/mdq577.
Gallagher DJ, Konner JA, Bell-McGuinn KM, Bhatia J, Sabbatini P, Aghajanian CA, et al. Survival in epithelial ovarian cancer: a multivariate analysis incorporating BRCA mutation status and platinum sensitivity. Annals of oncology : official journal of the European Society for Medical Oncology. 2011 May;22(5):1127–32.
Gallagher, D. J., et al. “Survival in epithelial ovarian cancer: a multivariate analysis incorporating BRCA mutation status and platinum sensitivity.Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 22, no. 5, May 2011, pp. 1127–32. Epmc, doi:10.1093/annonc/mdq577.
Gallagher DJ, Konner JA, Bell-McGuinn KM, Bhatia J, Sabbatini P, Aghajanian CA, Offit K, Barakat RR, Spriggs DR, Kauff ND. Survival in epithelial ovarian cancer: a multivariate analysis incorporating BRCA mutation status and platinum sensitivity. Annals of oncology : official journal of the European Society for Medical Oncology. 2011 May;22(5):1127–1132.
Journal cover image

Published In

Annals of oncology : official journal of the European Society for Medical Oncology

DOI

EISSN

1569-8041

ISSN

0923-7534

Publication Date

May 2011

Volume

22

Issue

5

Start / End Page

1127 / 1132

Related Subject Headings

  • Platinum
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
  • Multivariate Analysis
  • Middle Aged
  • Kaplan-Meier Estimate
  • INDEL Mutation
  • Humans