Unified biophysical mechanism for cell-shape oscillations and cell ingression.

Published

Journal Article

We describe a mechanochemical and percolation cascade that augments myosin's regulatory network to tune cytoskeletal forces. Actomyosin forces collectively generate cytoskeletal forces during cell oscillations and ingression, which we quantify by elastic percolation of the internally driven, cross-linked actin network. Contractile units can produce relatively large, oscillatory forces that disrupt crosslinks to reduce cytoskeletal forces. A (reverse) Hopf bifurcation switches contractile units to produce smaller, steady forces that enhance crosslinking and consequently boost cytoskeletal forces to promote ingression. We describe cell-shape changes and cell ingression in terms of intercellular force imbalances along common cell junctions.

Full Text

Duke Authors

Cited Authors

  • Lo, W-C; Madrak, C; Kiehart, DP; Edwards, GS

Published Date

  • June 2018

Published In

Volume / Issue

  • 97 / 6-1

Start / End Page

  • 062414 -

PubMed ID

  • 30011599

Pubmed Central ID

  • 30011599

Electronic International Standard Serial Number (EISSN)

  • 2470-0053

International Standard Serial Number (ISSN)

  • 2470-0045

Digital Object Identifier (DOI)

  • 10.1103/PhysRevE.97.062414

Language

  • eng