Unified biophysical mechanism for cell-shape oscillations and cell ingression.
Journal Article (Journal Article)
We describe a mechanochemical and percolation cascade that augments myosin's regulatory network to tune cytoskeletal forces. Actomyosin forces collectively generate cytoskeletal forces during cell oscillations and ingression, which we quantify by elastic percolation of the internally driven, cross-linked actin network. Contractile units can produce relatively large, oscillatory forces that disrupt crosslinks to reduce cytoskeletal forces. A (reverse) Hopf bifurcation switches contractile units to produce smaller, steady forces that enhance crosslinking and consequently boost cytoskeletal forces to promote ingression. We describe cell-shape changes and cell ingression in terms of intercellular force imbalances along common cell junctions.
Full Text
Duke Authors
Cited Authors
- Lo, W-C; Madrak, C; Kiehart, DP; Edwards, GS
Published Date
- June 2018
Published In
Volume / Issue
- 97 / 6-1
Start / End Page
- 062414 -
PubMed ID
- 30011599
Pubmed Central ID
- PMC6440536
Electronic International Standard Serial Number (EISSN)
- 2470-0053
International Standard Serial Number (ISSN)
- 2470-0045
Digital Object Identifier (DOI)
- 10.1103/physreve.97.062414
Language
- eng