Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium.

Journal Article (Journal Article)

The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.

Full Text

Duke Authors

Cited Authors

  • Hollmann, JL; Horstmeyer, R; Yang, C; DiMarzio, CA

Published Date

  • February 2013

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 25004 -

PubMed ID

  • 23400416

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.jbo.18.2.025004


  • eng