Association of cardiovascular responses in mice with source-apportioned pm2.5 air pollution in beijing

Conference Paper

© 2018, AAGR Aerosol and Air Quality Research. All rights reserved. In this study, factor analysis and mass regression were used to identify four fine particulate matter sources and estimate their contributions to the ambient air pollution in Beijing. The identified sources were traffic re-suspended soil, mixed industrial sources, oil combustion, and secondary sulfate. The estimated source contributions were then introduced into two models as exposure variables to explore the relationships between cardiovascular responses in mice and PM exposures. We observed that PM2.5 has a small negative acute effect on heart rate, but the individual source factors showed much more significant effects. Traffic re-suspended soil had the most significant effect on heart rate, with a positive contribution on the day of exposure and a negative one on day lag 1. Acute heart rate variability outcomes were better explained by the total PM2.5 than by the source components. Chronic effects were observed as a decreased heart rate but an increased number of heart rate variability outcomes.

Full Text

Duke Authors

Cited Authors

  • Maciejczyk, P; Jin, L; Hwang, JS; Guo, X; Zhong, M; Thurston, G; Qu, Q; Zhang, J; Sun, Q; Chen, LC

Published Date

  • June 1, 2018

Published In

Volume / Issue

  • 18 / 7

Start / End Page

  • 1839 - 1852

Electronic International Standard Serial Number (EISSN)

  • 2071-1409

International Standard Serial Number (ISSN)

  • 1680-8584

Digital Object Identifier (DOI)

  • 10.4209/aaqr.2017.11.0504

Citation Source

  • Scopus