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Composition of Exfoliation Material.

Publication ,  Journal Article
Challa, P; Johnson, WM
Published in: J Glaucoma
July 2018

Exfoliation glaucoma (XFG) is the most common identifiable cause of open-angle glaucoma worldwide, and results from the accumulation of extracellular fibrillary material (XFM) within the trabecular meshwork and the Schlemm canal leading to increased intraocular pressure and potential blindness. Immunohistochemical and mass spectrometry analyses have revealed that XFM is a highly glycosylated proteinaceous complex that is extremely resistant to degradation both within the body and under experimental conditions. The protein core contains a wide variety of proteins, including basement membrane proteins, elastic fiber proteins, latent TGFβ proteins, metalloproteinases, chaperone proteins, complement proteins, lysyl oxidase-like 1 (LOXL1), and apolipoprotein E (ApoE). This supplemental section identifies the advances in knowledge and current understanding of the components within XFM with a specific focus on the most recent work defining proteins within XFM and to pose several biological questions that remain unanswered.

Duke Scholars

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

July 2018

Volume

27 Suppl 1

Start / End Page

S29 / S31

Location

United States

Related Subject Headings

  • Protein Aggregation, Pathological
  • Protein Aggregates
  • Ophthalmology & Optometry
  • Humans
  • Glaucoma, Open-Angle
  • Exfoliation Syndrome
  • Anterior Eye Segment
  • Amino Acid Oxidoreductases
  • 3212 Ophthalmology and optometry
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Challa, P., & Johnson, W. M. (2018). Composition of Exfoliation Material. J Glaucoma, 27 Suppl 1, S29–S31. https://doi.org/10.1097/IJG.0000000000000917
Challa, Pratap, and William M. Johnson. “Composition of Exfoliation Material.J Glaucoma 27 Suppl 1 (July 2018): S29–31. https://doi.org/10.1097/IJG.0000000000000917.
Challa P, Johnson WM. Composition of Exfoliation Material. J Glaucoma. 2018 Jul;27 Suppl 1:S29–31.
Challa, Pratap, and William M. Johnson. “Composition of Exfoliation Material.J Glaucoma, vol. 27 Suppl 1, July 2018, pp. S29–31. Pubmed, doi:10.1097/IJG.0000000000000917.
Challa P, Johnson WM. Composition of Exfoliation Material. J Glaucoma. 2018 Jul;27 Suppl 1:S29–S31.

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

July 2018

Volume

27 Suppl 1

Start / End Page

S29 / S31

Location

United States

Related Subject Headings

  • Protein Aggregation, Pathological
  • Protein Aggregates
  • Ophthalmology & Optometry
  • Humans
  • Glaucoma, Open-Angle
  • Exfoliation Syndrome
  • Anterior Eye Segment
  • Amino Acid Oxidoreductases
  • 3212 Ophthalmology and optometry
  • 1103 Clinical Sciences