Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense.

Journal Article (Journal Article;Review)

Once pathogens have breached the mechanical barriers to infection, survived extracellular immunity and successfully invaded host cells, cell-intrinsic immunity becomes the last line of defense to protect the mammalian host against viruses, bacteria, fungi and protozoa. Many cell-intrinsic defense programs act as high-precision weapons that specifically target intracellular microbes or cytoplasmic sites of microbial replication while leaving endogenous organelles unharmed. Critical executioners of cell-autonomous immunity include interferon-inducible dynamin-like GTPases and autophagy proteins, which often act cooperatively in locating and antagonizing intracellular pathogens. Here, we discuss possible mechanistic models to account for the functional interactions that occur between these two distinct classes of host defense proteins.

Full Text

Duke Authors

Cited Authors

  • Coers, J; Brown, HM; Hwang, S; Taylor, GA

Published Date

  • October 2018

Published In

Volume / Issue

  • 54 /

Start / End Page

  • 93 - 101

PubMed ID

  • 29986303

Pubmed Central ID

  • PMC6196122

Electronic International Standard Serial Number (EISSN)

  • 1879-0372

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2018.06.008


  • eng

Conference Location

  • England