Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.

Published online

Journal Article

Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.

Full Text

Duke Authors

Cited Authors

  • Naggie, S; Swiderska-Syn, M; Choi, S; Lusk, S; Lan, A; Ferrari, G; Syn, W-K; Guy, CD; Diehl, AM

Published Date

  • July 2018

Published In

Volume / Issue

  • 5 / 7

Start / End Page

  • ofy138 -

PubMed ID

  • 29992177

Pubmed Central ID

  • 29992177

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofy138

Language

  • eng

Conference Location

  • United States