Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.
Published online
Journal Article
Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.
Full Text
Duke Authors
Cited Authors
- Naggie, S; Swiderska-Syn, M; Choi, S; Lusk, S; Lan, A; Ferrari, G; Syn, W-K; Guy, CD; Diehl, AM
Published Date
- July 2018
Published In
Volume / Issue
- 5 / 7
Start / End Page
- ofy138 -
PubMed ID
- 29992177
Pubmed Central ID
- 29992177
International Standard Serial Number (ISSN)
- 2328-8957
Digital Object Identifier (DOI)
- 10.1093/ofid/ofy138
Language
- eng
Conference Location
- United States