Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.


Journal Article

Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.

Full Text

Duke Authors

Cited Authors

  • Naggie, S; Swiderska-Syn, M; Choi, S; Lusk, S; Lan, A; Ferrari, G; Syn, W-K; Guy, CD; Diehl, AM

Published Date

  • July 2018

Published In

Volume / Issue

  • 5 / 7

Start / End Page

  • ofy138 -

PubMed ID

  • 29992177

Pubmed Central ID

  • 29992177

Electronic International Standard Serial Number (EISSN)

  • 2328-8957

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofy138


  • eng