Detection of Bladder Contractions From the Activity of the External Urethral Sphincter in Rats Using Sparse Regression.

Journal Article (Journal Article)

Bladder overactivity and incontinence and dysfunction can be mitigated by electrical stimulation of the pudendal nerve applied at the onset of a bladder contraction. Thus, it is important to predict accurately both bladder pressure and the onset of bladder contractions. We propose a novel method for prediction of bladder pressure using a time-dependent spectrogram representation of external urethral sphincter electromyographic (EUS EMG) activity and a least absolute shrinkage and selection operator regression model. There was a statistically significant improvement in prediction of bladder pressure compared with methods based on the firing rate of EUS EMG activity. This approach enabled prediction of the onset of bladder contractions with 91% specificity and 96% sensitivity and may be suitable for closed-loop control of bladder continence.

Full Text

Duke Authors

Cited Authors

  • Rutter, EM; Langdale, CL; Hokanson, JA; Hamilton, F; Tran, H; Grill, WM; Flores, KB

Published Date

  • August 2018

Published In

Volume / Issue

  • 26 / 8

Start / End Page

  • 1636 - 1644

PubMed ID

  • 30004881

Pubmed Central ID

  • PMC6531051

Electronic International Standard Serial Number (EISSN)

  • 1558-0210

International Standard Serial Number (ISSN)

  • 1534-4320

Digital Object Identifier (DOI)

  • 10.1109/tnsre.2018.2854675


  • eng