Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.

Published

Journal Article

Long noncoding RNA (lncRNA) is yet to be linked to cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA is associated with the cytosolic cyclin-dependent kinase CDK6 and regulated CDK6-dependent phosphorylation of the fructose bisphosphatase PFK2 (PFKFB3) in a cell-cycle-independent manner. In breast cancer cells, these events promoted catalysis of glucose 6-phosphate to fructose-2,6-bisphosphate/fructose-1,6-bisphosphate. CRISPR/Cas9-mediated deletion of YIYA or CDK6 silencing impaired glycolysis and tumor growth in vivo In clinical specimens of breast cancer, YIYA was expressed in approximately 40% of cases where it correlated with CDK6 expression and unfavorable survival outcomes. Our results define a functional role for lncRNA in metabolic reprogramming in cancer, with potential clinical implications for its therapeutic targeting.Significance: These findings offer a first glimpse into how a long-coding RNA influences cancer metabolism to drive tumor growth. Cancer Res; 78(16); 4524-32. ©2018 AACR.

Full Text

Duke Authors

Cited Authors

  • Xing, Z; Zhang, Y; Liang, K; Yan, L; Xiang, Y; Li, C; Hu, Q; Jin, F; Putluri, V; Putluri, N; Coarfa, C; Sreekumar, A; Park, PK; Nguyen, TK; Wang, S; Zhou, J; Zhou, Y; Marks, JR; Hawke, DH; Hung, M-C; Yang, L; Han, L; Ying, H; Lin, C

Published Date

  • August 15, 2018

Published In

Volume / Issue

  • 78 / 16

Start / End Page

  • 4524 - 4532

PubMed ID

  • 29967256

Pubmed Central ID

  • 29967256

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-17-0385

Language

  • eng

Conference Location

  • United States