Skip to main content
Journal cover image

Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.

Publication ,  Journal Article
Okeke, NL; Alenezi, F; Bloomfield, GS; Dunning, A; Clement, ME; Shah, SH; Naggie, S; Velazquez, EJ
Published in: J Card Fail
August 2018

OBJECTIVE: The aim of this work was to investigate determinants of structural myocardial abnormalities in persons living with human immunodeficiency virus (PLWH). METHODS AND RESULTS: We reviewed archived transthoracic echocardiograms (TTEs) performed on PLWH at Duke University Medical Center from 2001 to 2012. The primary outcomes were presence of left ventricular hypertrophy (LVH) or diastolic dysfunction (DD). TTEs for 498 human immunodeficiency virus-infected persons were reviewed (median age 44 years, 38% female, 72% black, 34% with hypertension, 15% with diabetes). Among those with usable images, LVH was detected in 174 of 473 persons (37%) according to LV mass criteria and in 99 of 322 persons (31%) according to American Society of Echocardiography LV mass index criteria. Definite DD was detected in 18 of 224 persons (8%). LVH was more common in PLWH with a CD4 count ≤ 200 cells/mm3 proximal to TTE (adjusted OR 1.68, 95% CI 1.08-2.62), CD4 nadir ≤ 200 cells/mm3 (adjusted OR 1.63, 95% CI 1.04-2.54) and less common in persons with viral suppression (OR 0.46, 95% CI 0.27-0.80). Lower CD4 nadirs (P = .002) and proximal CD4 counts (P = .002) were also associated with DD. CONCLUSIONS: Persons with a history of advanced human immunodeficiency virus-associated immune suppression are at higher risk of LVH and DD than infected persons with preserved immune function.

Duke Scholars

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

August 2018

Volume

24

Issue

8

Start / End Page

496 / 503

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • United States
  • Retrospective Studies
  • RNA, Viral
  • Prevalence
  • Male
  • Hypertrophy, Left Ventricular
  • Humans
  • Heart Ventricles
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Okeke, N. L., Alenezi, F., Bloomfield, G. S., Dunning, A., Clement, M. E., Shah, S. H., … Velazquez, E. J. (2018). Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort. J Card Fail, 24(8), 496–503. https://doi.org/10.1016/j.cardfail.2018.06.003
Okeke, Nwora Lance, Fawaz Alenezi, Gerald S. Bloomfield, Allison Dunning, Meredith E. Clement, Svati H. Shah, Susanna Naggie, and Eric J. Velazquez. “Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.J Card Fail 24, no. 8 (August 2018): 496–503. https://doi.org/10.1016/j.cardfail.2018.06.003.
Okeke NL, Alenezi F, Bloomfield GS, Dunning A, Clement ME, Shah SH, et al. Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort. J Card Fail. 2018 Aug;24(8):496–503.
Okeke, Nwora Lance, et al. “Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.J Card Fail, vol. 24, no. 8, Aug. 2018, pp. 496–503. Pubmed, doi:10.1016/j.cardfail.2018.06.003.
Okeke NL, Alenezi F, Bloomfield GS, Dunning A, Clement ME, Shah SH, Naggie S, Velazquez EJ. Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort. J Card Fail. 2018 Aug;24(8):496–503.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

August 2018

Volume

24

Issue

8

Start / End Page

496 / 503

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • United States
  • Retrospective Studies
  • RNA, Viral
  • Prevalence
  • Male
  • Hypertrophy, Left Ventricular
  • Humans
  • Heart Ventricles
  • HIV Infections