Chronic Myeloid Leukemia Following Treatment for Primary Neoplasms or Other Medical Conditions.

Journal Article (Journal Article)

OBJECTIVES: Therapy-related chronic myeloid leukemia (CML) has been reported, but its clinical presentation and pathologic features have not yet been well characterized. METHODS: Twenty-one cases of CML following treatment for primary diseases were collected and retrospectively analyzed. RESULTS: The clinical presentation, pathologic features, and cytogenetic profile were similar to de novo CML. In particular, those with an isolated Philadelphia chromosome constituted 88.9% of our cases, and additional aberrations characteristic of therapy-related acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) were not identified in this study. The patients responded to imatinib/derivatives and survived with limited follow-up. CONCLUSIONS: Therapy-related CML has a clinical presentation, pathologic features, and cytogenetic profile akin to de novo CML. Absence of additional significant aberrations seems to suggest a pathogenesis different from therapy-related AML/MDS. Therapy-related CML exhibits a robust therapeutic response to imatinib/derivatives and favorable clinical outcomes similar to de novo CML.

Full Text

Duke Authors

Cited Authors

  • Yang, L-H; Su, P; Luedke, C; Lu, CM; Louissaint, A; McCall, CM; Rapisardo, S; Vallangeon, B; Wang, E

Published Date

  • July 31, 2018

Published In

Volume / Issue

  • 150 / 3

Start / End Page

  • 246 - 258

PubMed ID

  • 29992292

Electronic International Standard Serial Number (EISSN)

  • 1943-7722

Digital Object Identifier (DOI)

  • 10.1093/ajcp/aqy050


  • eng

Conference Location

  • England