Chronic Myeloid Leukemia Following Treatment for Primary Neoplasms or Other Medical Conditions: A Report of 21 Cases and Review of the Literature.
Therapy-related chronic myeloid leukemia (CML) has been reported, but its clinical presentation and pathologic features have not yet been well characterized.Twenty-one cases of CML following treatment for primary diseases were collected and retrospectively analyzed.The clinical presentation, pathologic features, and cytogenetic profile were similar to de novo CML. In particular, those with an isolated Philadelphia chromosome constituted 88.9% of our cases, and additional aberrations characteristic of therapy-related acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) were not identified in this study. The patients responded to imatinib/derivatives and survived with limited follow-up.Therapy-related CML has a clinical presentation, pathologic features, and cytogenetic profile akin to de novo CML. Absence of additional significant aberrations seems to suggest a pathogenesis different from therapy-related AML/MDS. Therapy-related CML exhibits a robust therapeutic response to imatinib/derivatives and favorable clinical outcomes similar to de novo CML.
Yang, L-H; Su, P; Luedke, C; Lu, CM; Louissaint, A; McCall, CM; Rapisardo, S; Vallangeon, B; Wang, E
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