Evaluation of a Botanical Extract that Mimics the Respiratory Cues of Cigarette Smoke


Journal Article

Copyright © 2018 The Author(s). Introduction: Cigarette addiction results from both pharmacological effects of nicotine and the rewarding effects of associated cues, including respiratory tract sensations. Aims: This study sought to evaluate the initial acceptability of a non-nicotine botanical formulation that provided similar respiratory tract cues. Methods: Two active test products and matching placebos were evaluated. One test product, an e-cigarette-like device, delivered a visible aerosol upon puffing; the other test product delivered an invisible vapour at ambient temperature. Test products delivered a botanical extract with flavourings and vehicle; the placebos delivered flavourings and vehicle only. Sixteen participants had 3-h ad libitum access to each test product and associated placebos, and were deprived of combustible cigarettes for 1 h before and throughout the 3-h evaluation period. Subjects rated the satisfaction (primary outcome) and other sensory qualities of the products. Safety evaluations included pulmonary function testing and monitoring vital signs. Results: Satisfaction ratings (seven-point scale) were significantly greater for the active e-cigarette-like condition; M = 3.18, SD = 1.04 versus M = 2.69, SD = 1.22. Safety evaluations showed no clinically significant changes. Conclusions: The results support the potential acceptability of a non-nicotine cigarette substitute in providing satisfaction to smokers. This approach merits further evaluation for safety and acceptability in tobacco harm reduction and cessation.

Full Text

Duke Authors

Cited Authors

  • Rose, JE; Willette, PN; Loeback, TH; Botts, DR

Published Date

  • March 1, 2019

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 59 - 64

Electronic International Standard Serial Number (EISSN)

  • 1834-2612

Digital Object Identifier (DOI)

  • 10.1017/jsc.2018.14

Citation Source

  • Scopus