Effects of classical and atypical antipsychotic drugs on isolation-induced aggression in male mice.

Journal Article (Journal Article)

A series of classical, atypical and putative antipsychotic drugs were compared for their ability to inhibit isolation-induced intraspecies aggression with affinity for D-2 dopamine receptors and induction of akinesia. The majority of drugs tested significantly inhibited aggressive behavior only after doses that greatly decreased the ability of mice to move. Even though akinesia seemed to account for inhibition of aggression there was no apparent correlation with binding to striatal D-2 receptors.

Full Text

Duke Authors

Cited Authors

  • McMillen, BA; DaVanzo, EA; Song, AH; Scott, SM; Rodriguez, ME

Published Date

  • January 24, 1989

Published In

Volume / Issue

  • 160 / 1

Start / End Page

  • 149 - 153

PubMed ID

  • 2565815

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(89)90664-x


  • eng

Conference Location

  • Netherlands