Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals.

Journal Article (Journal Article)

Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties. The extract produced an inhibition of carrageenan-induced edema in the rat paw over a dose range of 10-300 mg/kg i.p.; the dose-response curve was bell-shaped with a maximal effect at 100 mg/kg. The extract also produced a small but significant increase in the response latency of rats subjected to the hot plate, a thermal pain test that only detects analgesia by high-efficacy agents. The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans.

Duke Authors

Cited Authors

  • Uzcátegui, B; Avila, D; Suárez-Roca, H; Quintero, L; Ortega, J; González, B

Published Date

  • December 2004

Published In

Volume / Issue

  • 45 / 4

Start / End Page

  • 317 - 322

PubMed ID

  • 15602898

International Standard Serial Number (ISSN)

  • 0535-5133


  • eng