The Optimal Timing of Stage-2-Palliation After the Norwood Operation.

Journal Article (Multicenter Study;Journal Article)


The effect of the timing of stage-2-palliation (S2P) on survival through single ventricle palliation remains unknown. This study investigated the optimal timing of S2P that minimizes pre-S2P attrition and maximizes post-S2P survival.


The Congenital Heart Surgeons' Society's critical left ventricular outflow tract obstruction cohort was used. Survival analysis was performed using multiphase parametric hazard analysis. Separate risk factors for death after the Norwood and after S2P were identified. Based on the multivariable models, infants were stratified as low, intermediate, or high risk. Cumulative 2-year, post-Norwood survival was predicted. Optimal timing was determined using conditional survival analysis and plotted as 2-year, post-Norwood survival versus age at S2P.


A Norwood operation was performed in 534 neonates from 21 institutions. The S2P was performed in 71%, at a median age of 5.1 months (IQR: 4.3 to 6.0), and 22% died after Norwood. By 5 years after S2P, 10% of infants had died. For low- and intermediate-risk infants, performing S2P after age 3 months was associated with 89% ± 3% and 82% ± 3% 2-year survival, respectively. Undergoing an interval cardiac reoperation or moderate-severe right ventricular dysfunction before S2P were high-risk features. Among high-risk infants, 2-year survival was 63% ± 5%, and even lower when S2P was performed before age 6 months.


Performing S2P after age 3 months may optimize survival of low- and intermediate-risk infants. High-risk infants are unlikely to complete three-stage palliation, and early S2P may increase their risk of mortality. We infer that early referral for cardiac transplantation may increase their chance of survival.

Full Text

Duke Authors

Cited Authors

  • Meza, JM; Hickey, E; McCrindle, B; Blackstone, E; Anderson, B; Overman, D; Kirklin, JK; Karamlou, T; Caldarone, C; Kim, R; DeCampli, W; Jacobs, M; Guleserian, K; Jacobs, JP; Jaquiss, R; Congenital Heart Surgeons’ Society Timing of S2P Working Group,

Published Date

  • January 2018

Published In

Volume / Issue

  • 105 / 1

Start / End Page

  • 193 - 199

PubMed ID

  • 28847537

Pubmed Central ID

  • PMC6594160

Electronic International Standard Serial Number (EISSN)

  • 1552-6259

International Standard Serial Number (ISSN)

  • 0003-4975

Digital Object Identifier (DOI)

  • 10.1016/j.athoracsur.2017.05.041


  • eng