Effects of Exercise Restriction on Patients With Anomalous Aortic Origin of a Coronary Artery.

Journal Article (Journal Article)


Management of young patients with anomalous aortic origin of a coronary artery (AAOCA) may involve exercise restriction. We sought to identify the association of exercise restriction with changes over time in body mass index (BMI) and exercise capacity in this cohort.


We performed a retrospective review of patients with AAOCA seen at The Children's Hospital of Philadelphia between January 1, 1998, and August 31, 2014. Linear mixed model repeated-measures analysis assessed changes in BMI and exercise capacity.


We included 72 patients with a median age at presentation of 12.6 years (interquartile range: 10.1-15.8) and mean follow-up of 3.6 ± 3.0 years. The majority had an anomalous right coronary artery (71%) and interarterial ± intramural coronary course (90%). Surgery was performed in 54%, more often in those with interarterial/intramural course ( P < .001) and symptoms ( P = .003). Most patients (82%) were exercise-restricted on presentation, and restricted patients were older than those who were not restricted ( P = .01). There was no significant difference between restricted and nonrestricted patients in initial BMI z scores, percentage of patients with BMI over 85th percentile (26%) or exercise capacity variables. In univariable analysis, exercise restriction over time was not associated with change in BMI z score ( P = .25) or change in exercise variables. Restriction was not associated with significant change in these variables in multivariable analysis.


Although further investigation is warranted to determine the degree of adherence to exercise restriction, the recommendation of restriction alone is not associated with increasing BMI or decreasing exercise performance in the short-term.

Full Text

Duke Authors

Cited Authors

  • Elias, MD; Meza, J; McCrindle, BW; Brothers, JA; Paridon, S; Cohen, MS

Published Date

  • January 2017

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 18 - 24

PubMed ID

  • 28033084

Electronic International Standard Serial Number (EISSN)

  • 2150-136X

International Standard Serial Number (ISSN)

  • 2150-1351

Digital Object Identifier (DOI)

  • 10.1177/2150135116674444


  • eng