Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Published online

Journal Article

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.

Full Text

Cited Authors

  • Dominguez-Salas, P; Moore, SE; Baker, MS; Bergen, AW; Cox, SE; Dyer, RA; Fulford, AJ; Guan, Y; Laritsky, E; Silver, MJ; Swan, GE; Zeisel, SH; Innis, SM; Waterland, RA; Prentice, AM; Hennig, BJ

Published Date

  • April 29, 2014

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 3746 -

PubMed ID

  • 24781383

Pubmed Central ID

  • 24781383

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms4746

Language

  • eng

Conference Location

  • England