Post-irradiation morphoea of the breast: a case report and review of the literature.
Journal Article (Journal Article;Review)
We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Clinically, PIM is misdiagnosed commonly as lymphoedema and cellulitis in the early inflammatory phase, and recurrent breast cancer, chronic radiodermatitis (CRD), radiation-induced fibrosis (RIF), post-irradiation pseudosclerodermatous panniculitis (PIPP), atypical vascular lesions (AVL) or angiosarcoma (AS) in the late burnout phase. Arriving at the correct diagnosis typically requires a multidisciplinary approach, including a skin biopsy for confirmation. To date, satisfactory treatment of this condition has been challenging. and the clinical outcome after therapy is often unsatisfactory.
Full Text
Duke Authors
Cited Authors
- Gonzalez-Ericsson, PI; Estrada, MV; Al-Rohil, R; Sanders, ME
Published Date
- January 2018
Published In
Volume / Issue
- 72 / 2
Start / End Page
- 342 - 350
PubMed ID
- 29110314
Pubmed Central ID
- 29110314
Electronic International Standard Serial Number (EISSN)
- 1365-2559
Digital Object Identifier (DOI)
- 10.1111/his.13343
Language
- eng
Conference Location
- England