Cancer Liquid Biopsy: Is It Ready for Clinic?

Journal Article (Journal Article)

The management of cancer relies on a combination of imaging and tissue biopsy for diagnosis, monitoring, and molecular classification-based patient stratification to ensure appropriate treatment. Conventional tissue biopsy harvests tumor samples with invasive procedures, which are often difficult for patients with advanced disease. Given the well-recognized intratumor genetic heterogeneity [1], the biopsy of small tumor fragments does not necessarily represent all the genetic aberrations in the tumor, but sampling the entire tumor in each patient is not realistic. Moreover, tumors evolve all the time from local to advanced disease and by adapting to selective pressure from treatment.

Full Text

Duke Authors

Cited Authors

  • Pan, Y; Ji, JS; Jin, JG; Kuo, WP; Kang, H

Published Date

  • January 2017

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 23 - 27

PubMed ID

  • 28129138

Electronic International Standard Serial Number (EISSN)

  • 2154-2317

International Standard Serial Number (ISSN)

  • 2154-2287

Digital Object Identifier (DOI)

  • 10.1109/mpul.2016.2630838


  • eng