Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.

Published

Journal Article

Euphorbia kansui showed potent anti-HIV-1 activity during screening of a library composed of plant extracts from Euphorbiaceae and Thymelaeaceae families. Bioassay-guided isolation led to identification of ingenane esters as the active compounds. Further chemical modification resulted in 3-(2-naphthoyl)ingenol (23), which exhibited the most potent anti-HIV-1 activity. Compound 23 also acted as an HIV-1-latency-reversing agent on activation of HIV-1 replication in a latently infected U1 cell model and a T cell latent HIV-1 model JLat-A2.

Full Text

Duke Authors

Cited Authors

  • Liu, Q; Li, W; Huang, L; Asada, Y; Morris-Natschke, SL; Chen, C-H; Lee, K-H; Koike, K

Published Date

  • August 2018

Published In

Volume / Issue

  • 156 /

Start / End Page

  • 618 - 627

PubMed ID

  • 30031972

Pubmed Central ID

  • 30031972

Electronic International Standard Serial Number (EISSN)

  • 1768-3254

International Standard Serial Number (ISSN)

  • 0223-5234

Digital Object Identifier (DOI)

  • 10.1016/j.ejmech.2018.07.020

Language

  • eng