Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.
Journal Article (Journal Article)
Euphorbia kansui showed potent anti-HIV-1 activity during screening of a library composed of plant extracts from Euphorbiaceae and Thymelaeaceae families. Bioassay-guided isolation led to identification of ingenane esters as the active compounds. Further chemical modification resulted in 3-(2-naphthoyl)ingenol (23), which exhibited the most potent anti-HIV-1 activity. Compound 23 also acted as an HIV-1-latency-reversing agent on activation of HIV-1 replication in a latently infected U1 cell model and a T cell latent HIV-1 model JLat-A2.
Full Text
Duke Authors
Cited Authors
- Liu, Q; Li, W; Huang, L; Asada, Y; Morris-Natschke, SL; Chen, C-H; Lee, K-H; Koike, K
Published Date
- August 5, 2018
Published In
Volume / Issue
- 156 /
Start / End Page
- 618 - 627
PubMed ID
- 30031972
Pubmed Central ID
- PMC6217806
Electronic International Standard Serial Number (EISSN)
- 1768-3254
Digital Object Identifier (DOI)
- 10.1016/j.ejmech.2018.07.020
Language
- eng
Conference Location
- France