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Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.

Publication ,  Journal Article
Liu, Q; Li, W; Huang, L; Asada, Y; Morris-Natschke, SL; Chen, C-H; Lee, K-H; Koike, K
Published in: Eur J Med Chem
August 5, 2018

Euphorbia kansui showed potent anti-HIV-1 activity during screening of a library composed of plant extracts from Euphorbiaceae and Thymelaeaceae families. Bioassay-guided isolation led to identification of ingenane esters as the active compounds. Further chemical modification resulted in 3-(2-naphthoyl)ingenol (23), which exhibited the most potent anti-HIV-1 activity. Compound 23 also acted as an HIV-1-latency-reversing agent on activation of HIV-1 replication in a latently infected U1 cell model and a T cell latent HIV-1 model JLat-A2.

Duke Scholars

Published In

Eur J Med Chem

DOI

EISSN

1768-3254

Publication Date

August 5, 2018

Volume

156

Start / End Page

618 / 627

Location

France

Related Subject Headings

  • Virus Replication
  • Plant Extracts
  • Medicinal & Biomolecular Chemistry
  • Humans
  • HIV-1
  • HIV Infections
  • Euphorbia
  • Esters
  • Diterpenes
  • Cell Line
 

Citation

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Liu, Q., Li, W., Huang, L., Asada, Y., Morris-Natschke, S. L., Chen, C.-H., … Koike, K. (2018). Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. Eur J Med Chem, 156, 618–627. https://doi.org/10.1016/j.ejmech.2018.07.020
Liu, Qingbo, Wei Li, Li Huang, Yoshihisa Asada, Susan L. Morris-Natschke, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.Eur J Med Chem 156 (August 5, 2018): 618–27. https://doi.org/10.1016/j.ejmech.2018.07.020.
Liu, Qingbo, et al. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.Eur J Med Chem, vol. 156, Aug. 2018, pp. 618–27. Pubmed, doi:10.1016/j.ejmech.2018.07.020.
Liu Q, Li W, Huang L, Asada Y, Morris-Natschke SL, Chen C-H, Lee K-H, Koike K. Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. Eur J Med Chem. 2018 Aug 5;156:618–627.
Journal cover image

Published In

Eur J Med Chem

DOI

EISSN

1768-3254

Publication Date

August 5, 2018

Volume

156

Start / End Page

618 / 627

Location

France

Related Subject Headings

  • Virus Replication
  • Plant Extracts
  • Medicinal & Biomolecular Chemistry
  • Humans
  • HIV-1
  • HIV Infections
  • Euphorbia
  • Esters
  • Diterpenes
  • Cell Line