Pulmonary blastomycosis presenting as primary lung cancer.

Journal Article (Journal Article)

BACKGROUND: Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentation of blastomycosis may easily be mistaken for other infectious or non-infectious etiologies. CASE PRESENTATION: We present the case of a 52-year-old African-American male and former smoker that presented to his primary care provider with a 2-week history of non-productive cough, night sweats and weight loss. Initially diagnosed with primary lung malignancy, the patient was subsequently found to have pulmonary blastomycosis mimicking lung cancer. The patient underwent a successful course of treatment with posaconazole. CONCLUSIONS: Chronic blastomycosis can present with clinical and radiographic features indistinguishable from thoracic malignancies. There is no clinical syndrome specific for blastomycosis, thus a high degree of suspicion is required for early diagnosis. In this case report, we review recent evidence in radiographic features, diagnostic considerations and treatment of the disease.

Full Text

Duke Authors

Cited Authors

  • Hussaini, SMQ; Madut, D; Tong, BC; Pavlisko, EN; Schell, WA; Perfect, JR; Thielman, NM

Published Date

  • July 18, 2018

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 336 -

PubMed ID

  • 30021526

Pubmed Central ID

  • PMC6052517

Electronic International Standard Serial Number (EISSN)

  • 1471-2334

Digital Object Identifier (DOI)

  • 10.1186/s12879-018-3244-0


  • eng

Conference Location

  • England