Co-occurring reasons for medication nonadherence within subgroups of patients with hyperlipidemia.

Published

Journal Article

Medication nonadherence is a significant clinical problem among individuals taking statins. Poor adherence is often attributable to several reasons, yet most adherence interventions target a single reason. Baseline data were examined from a randomized clinical trial of 236 patients with hyperlipidemia. A latent class analysis was then performed on patients reporting any nonadherence (n = 109). A 4-class solution provided the most optimal fit and differentiation of classes. Class 1 (N = 59, 54%) included patients who reported occasionally forgetting. Class 2 (N = 16, 14%) represented patients who were concerned about side effects. Class 3 (N = 17, 16%) represented patients who reported out-of-routine life events as contributing to nonadherence. Class 4 (N = 17, 16%) represented patients who endorsed a large number reasons indiscriminately. Class membership was almost uniformly unrelated to any patient demographic factors or treatment arm. Each cluster of reasons defining these patients may be best addressed through different intervention strategies.

Full Text

Duke Authors

Cited Authors

  • Blalock, DV; Bosworth, HB; Reeve, BB; Voils, CI

Published Date

  • April 2019

Published In

Volume / Issue

  • 42 / 2

Start / End Page

  • 291 - 299

PubMed ID

  • 30027389

Pubmed Central ID

  • 30027389

Electronic International Standard Serial Number (EISSN)

  • 1573-3521

Digital Object Identifier (DOI)

  • 10.1007/s10865-018-9954-3

Language

  • eng

Conference Location

  • United States