Coronary Disease and Modifying Cardiovascular Risk in Adult Congenital Heart Disease Patients: Should General Guidelines Apply?

Published

Journal Article (Review)

There are >1.4 million adult congenital heart disease (CHD; ACHD) patients living in the United States. Coronary artery disease (CAD) is at least as prevalent in ACHD patients as in the general population and has become a leading cause of their mortality. In the majority of cases, CAD in the ACHD population is driven by the presence of traditional cardiovascular disease (CVD) risk factors. 80% of ACHD patients have at least one CVD risk factor. Hypertension (HTN), obesity and physical inactivity are frequently seen in both pediatric and adult patients with CHD. Many ACHD patients demonstrate abnormal glucose metabolism and are at an increased risk for developing diabetes. Current guidelines for CVD risk assessment and prevention do not specifically mention patients with CHD but are likely applicable to most of these patients. Specific CHD populations have "high-risk" lesions that are associated with an increased risk of CVD complications and may warrant intensified screening and treatment. These include patients with a history of coarctation of the aorta or with prior coronary artery ostial manipulation (patients with a history of d-transposition of the great arteries or anomalous aortic origin of a coronary artery). The physiology of single ventricle patients is also poorly suited for the effects of superimposed CVD; these patients may benefit from intensified treatment of CVD risk factors, particularly HTN and obesity.

Full Text

Duke Authors

Cited Authors

  • Awerbach, JD; Krasuski, RA; Camitta, MGW

Published Date

  • September 2018

Published In

Volume / Issue

  • 61 / 3-4

Start / End Page

  • 300 - 307

PubMed ID

  • 30041020

Pubmed Central ID

  • 30041020

Electronic International Standard Serial Number (EISSN)

  • 1873-1740

International Standard Serial Number (ISSN)

  • 0033-0620

Digital Object Identifier (DOI)

  • 10.1016/j.pcad.2018.07.018

Language

  • eng