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Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus.

Publication ,  Journal Article
Eudy, AM; Siega-Riz, AM; Engel, SM; Franceschini, N; Howard, AG; Clowse, MEB; Petri, M
Published in: J Rheumatol
January 2019

OBJECTIVE: To estimate the effects of preconceptional cardiovascular (CV) health, measured by American Heart Association (AHA) guidelines, on pregnancy outcomes in women with systemic lupus erythematosus (SLE). METHODS: The study included patients in the Hopkins Lupus Pregnancy Cohort. Body mass index (BMI), total cholesterol, and blood pressure (BP) in the most recent clinic visit prior to conception or first trimester were used to determine CV health (ideal, intermediate, or poor health) based on AHA definitions. Outcomes included preterm birth, gestational age at birth, and small for gestational age (SGA). Multivariable linear and logistic regression models with generalized estimating equations estimated the association of each CV health factor and outcome. RESULTS: The analysis included 309 live births. There were 95 preterm births (31%), and of the 293 pregnancies with birth weights, 18% were SGA. Ideal BMI, total cholesterol, and BP were reported in 56%, 85%, and 51% of pregnancies, respectively. Intermediate BMI was associated with decreased odds of SGA (OR 0.26, 95% CI 0.11-0.63), adjusted for race and prednisone use. Intermediate/poor total cholesterol was associated with increased odds of preterm birth (OR 2.21, 95% CI 1.06-4.62). Intermediate/poor BP was associated with decreased gestational age at birth (β -0.96, 95% CI -1.62 to -0.29). CONCLUSION: Poor/intermediate preconception CV health affects pregnancy outcomes of preterm birth and SGA infants among women with SLE. Efforts to maintain BMI, total cholesterol, and BP within the recommended ideal range prior to pregnancy is important to improve pregnancy outcomes in women with SLE.

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Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

January 2019

Volume

46

Issue

1

Start / End Page

70 / 77

Location

Canada

Related Subject Headings

  • Risk Factors
  • Pregnancy Outcome
  • Pregnancy Complications
  • Pregnancy
  • Lupus Erythematosus, Systemic
  • Infant, Small for Gestational Age
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Eudy, A. M., Siega-Riz, A. M., Engel, S. M., Franceschini, N., Howard, A. G., Clowse, M. E. B., & Petri, M. (2019). Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus. J Rheumatol, 46(1), 70–77. https://doi.org/10.3899/jrheum.171066
Eudy, Amanda M., Anna Maria Siega-Riz, Stephanie M. Engel, Nora Franceschini, Annie Green Howard, Megan E. B. Clowse, and Michelle Petri. “Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus.J Rheumatol 46, no. 1 (January 2019): 70–77. https://doi.org/10.3899/jrheum.171066.
Eudy AM, Siega-Riz AM, Engel SM, Franceschini N, Howard AG, Clowse MEB, et al. Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus. J Rheumatol. 2019 Jan;46(1):70–7.
Eudy, Amanda M., et al. “Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus.J Rheumatol, vol. 46, no. 1, Jan. 2019, pp. 70–77. Pubmed, doi:10.3899/jrheum.171066.
Eudy AM, Siega-Riz AM, Engel SM, Franceschini N, Howard AG, Clowse MEB, Petri M. Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus. J Rheumatol. 2019 Jan;46(1):70–77.

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

January 2019

Volume

46

Issue

1

Start / End Page

70 / 77

Location

Canada

Related Subject Headings

  • Risk Factors
  • Pregnancy Outcome
  • Pregnancy Complications
  • Pregnancy
  • Lupus Erythematosus, Systemic
  • Infant, Small for Gestational Age
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Female