Digital acoustofluidics enables contactless and programmable liquid handling.

Journal Article (Journal Article)

For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack fluid rewritability, and the associated benefits of multi-path routing and re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed and the complexity of reaction test matrices. We present a contactless droplet transport and processing technique called digital acoustofluidics which dynamically manipulates droplets with volumes from 1 nL to 100 µL along any planar axis via acoustic-streaming-induced hydrodynamic traps, all in a contamination-free (lower than 10-10 % diffusion into the fluorinated carrier oil layer) and biocompatible (99.2% cell viability) manner. Hence, digital acoustofluidics can execute reactions on overlapping, non-contaminated, fluidic paths and can scale to perform massive interaction matrices within a single device.

Full Text

Duke Authors

Cited Authors

  • Zhang, SP; Lata, J; Chen, C; Mai, J; Guo, F; Tian, Z; Ren, L; Mao, Z; Huang, P-H; Li, P; Yang, S; Huang, TJ

Published Date

  • July 26, 2018

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 2928 -

PubMed ID

  • 30050088

Pubmed Central ID

  • PMC6062562

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

International Standard Serial Number (ISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-018-05297-z


  • eng