Establishing the Cause of Anemia in a Premature Newborn Infant.

Journal Article (Journal Article)

The three major causes of anemia in neonates are blood loss, decreased red blood cell production, and increased degradation of erythrocytes. Establishing the cause of anemia in a neonate born prematurely can be challenging. Clinically, fetomaternal hemorrhage (FMH) can be difficult to diagnose-the condition often presents only after the manifestation of severe fetal anemia. FMH can be confirmed by determining the fetal hemoglobin F fraction in the mother, which is traditionally performed using the Kleihauer-Betke test (KBT). Herein, we present a case study of a newborn baby boy of Dutch ethnicity with massive FMH and negative KBT result. The KBT result appeared to be false-negative due to AO antagonism. However, the results of an additional marker alpha-fetoprotein (AFP) test confirmed the diagnosis of massive FMH. Therefore, measuring AFP in maternal blood can be helpful in confirming FMH in unexplained anemia of the neonate.

Full Text

Duke Authors

Cited Authors

  • den Besten, G; van der Weide, K; Schuerman, FABA; Michael Cotten, C; Rondeel, JMM

Published Date

  • July 5, 2018

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • e74 - e77

PubMed ID

  • 29868870

Electronic International Standard Serial Number (EISSN)

  • 1943-7730

Digital Object Identifier (DOI)

  • 10.1093/labmed/lmy026


  • eng

Conference Location

  • England