Identification of nonvisual photomotor response cells in the vertebrate hindbrain.

Published

Journal Article

Nonvisual photosensation enables animals to sense light without sight. However, the cellular and molecular mechanisms of nonvisual photobehaviors are poorly understood, especially in vertebrate animals. Here, we describe the photomotor response (PMR), a robust and reproducible series of motor behaviors in zebrafish that is elicited by visual wavelengths of light but does not require the eyes, pineal gland, or other canonical deep-brain photoreceptive organs. Unlike the relatively slow effects of canonical nonvisual pathways, motor circuits are strongly and quickly (seconds) recruited during the PMR behavior. We find that the hindbrain is both necessary and sufficient to drive these behaviors. Using in vivo calcium imaging, we identify a discrete set of neurons within the hindbrain whose responses to light mirror the PMR behavior. Pharmacological inhibition of the visual cycle blocks PMR behaviors, suggesting that opsin-based photoreceptors control this behavior. These data represent the first known light-sensing circuit in the vertebrate hindbrain.

Full Text

Duke Authors

Cited Authors

  • Kokel, D; Dunn, TW; Ahrens, MB; Alshut, R; Cheung, CYJ; Saint-Amant, L; Bruni, G; Mateus, R; van Ham, TJ; Shiraki, T; Fukada, Y; Kojima, D; Yeh, J-RJ; Mikut, R; von Lintig, J; Engert, F; Peterson, RT

Published Date

  • February 2013

Published In

Volume / Issue

  • 33 / 9

Start / End Page

  • 3834 - 3843

PubMed ID

  • 23447595

Pubmed Central ID

  • 23447595

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.3689-12.2013

Language

  • eng