Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension.
Journal Article (Journal Article;Review)
Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion.
Full Text
Duke Authors
Cited Authors
- Onal, EM; Sag, AA; Sal, O; Yerlikaya, A; Afsar, B; Kanbay, M
Published Date
- 2017
Published In
Volume / Issue
- 39 / 3
Start / End Page
- 197 - 209
PubMed ID
- 28448184
Electronic International Standard Serial Number (EISSN)
- 1525-6006
Digital Object Identifier (DOI)
- 10.1080/10641963.2016.1246565
Language
- eng
Conference Location
- England