Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension.

Journal Article (Journal Article;Review)

Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion.

Full Text

Duke Authors

Cited Authors

  • Onal, EM; Sag, AA; Sal, O; Yerlikaya, A; Afsar, B; Kanbay, M

Published Date

  • 2017

Published In

Volume / Issue

  • 39 / 3

Start / End Page

  • 197 - 209

PubMed ID

  • 28448184

Electronic International Standard Serial Number (EISSN)

  • 1525-6006

Digital Object Identifier (DOI)

  • 10.1080/10641963.2016.1246565


  • eng

Conference Location

  • England