The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.


Journal Article (Review)

This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.

Full Text

Duke Authors

Cited Authors

  • Sag, AA; Sal, O; Kilic, Y; Onal, EM; Kanbay, M

Published Date

  • May 2017

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 530 - 533

PubMed ID

  • 28224730

Pubmed Central ID

  • 28224730

Electronic International Standard Serial Number (EISSN)

  • 1751-7176

Digital Object Identifier (DOI)

  • 10.1111/jch.12978


  • eng

Conference Location

  • United States