The role of sodium intake in nephrolithiasis: epidemiology, pathogenesis, and future directions.


Journal Article (Review)

The prevalence of nephrolithiasis has doubled over the last decade and the incidence in females now approaches that of males. Since dietary salt is lithogenic, a purported mechanism common to both genders is excess dietary sodium intake vis-a-vis processed and fast foods. Nephrolithiasis has far-reaching societal implications such as impact on gross domestic product due to days lost from work (stone disease commonly affects working adults), population-wide carcinogenic diagnostic and interventional radiation exposure (kidney stone disease is typically imaged with computed tomographic imaging and treated under imaging guidance and follow-up), and rising healthcare costs (surgical treatment will be indicated for a number of these patients). Therefore, primary prevention of kidney stone disease via dietary intervention is a low-cost public health initiative with massive societal implications. This primer aims to establish baseline epidemiologic and pathophysiologic principles to guide clinicians in sodium-directed primary prevention of kidney stone disease.

Full Text

Duke Authors

Cited Authors

  • Afsar, B; Kiremit, MC; Sag, AA; Tarim, K; Acar, O; Esen, T; Solak, Y; Covic, A; Kanbay, M

Published Date

  • November 2016

Published In

Volume / Issue

  • 35 /

Start / End Page

  • 16 - 19

PubMed ID

  • 27444735

Pubmed Central ID

  • 27444735

Electronic International Standard Serial Number (EISSN)

  • 1879-0828

Digital Object Identifier (DOI)

  • 10.1016/j.ejim.2016.07.001


  • eng

Conference Location

  • Netherlands