Atherosclerotic renal artery stenosis in the post-CORAL era part 1: the renal penumbra concept and next-generation functional diagnostic imaging.

Journal Article (Journal Article;Review)

After three neutral trials in which renal artery stenting failed to improve renal function or reduce cardiovascular and renal events, the controversy surrounding diagnosis and treatment of atherosclerotic renal artery stenosis and renovascular hypertension has led to paradigm shifts in the diagnostic algorithm. Noninvasive determination of earlier events (cortex hypoxia and renal artery hemodynamic changes) will supersede late sequelae (calcific stenosis, renal cortical thinning). Therefore, this review proposes the concept of renal penumbra in defining at-risk ischemic renal parenchyma. The complex field of functional renal magnetic resonance imaging will be reviewed succinctly in a clinician-directed fashion.

Full Text

Duke Authors

Cited Authors

  • Sag, AA; Inal, I; Okcuoglu, J; Rossignol, P; Ortiz, A; Afsar, B; Sos, TA; Kanbay, M

Published Date

  • April 2016

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 360 - 367

PubMed ID

  • 26944791

Electronic International Standard Serial Number (EISSN)

  • 1878-7436

Digital Object Identifier (DOI)

  • 10.1016/j.jash.2016.02.009


  • eng

Conference Location

  • United States