Evidence-based medical oncology and interventional radiology paradigms for liver-dominant colorectal cancer metastases.

Journal Article (Journal Article;Review)

Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is (limited) extrahepatic disease. Unfortunately, these patients carry a known risk of recurrence in the liver regardless of initial therapy choice. Therefore, there is a demand for minimally invasive, non-surgical, personalized cancer treatments to preserve quality of life in the induction, consolidation, and maintenance phases of cancer therapy. This report aims to review evidence-based conceptual, pharmacological, and technological paradigm shifts in parenteral and percutaneous treatment strategies as well as forthcoming evidence regarding next-generation systemic, locoregional, and local treatment approaches for this patient population.

Full Text

Duke Authors

Cited Authors

  • Sag, AA; Selcukbiricik, F; Mandel, NM

Published Date

  • March 21, 2016

Published In

Volume / Issue

  • 22 / 11

Start / End Page

  • 3127 - 3149

PubMed ID

  • 27003990

Pubmed Central ID

  • PMC4789988

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

Digital Object Identifier (DOI)

  • 10.3748/wjg.v22.i11.3127


  • eng

Conference Location

  • United States