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Discriminating imagined from perceived information engages brain areas implicated in schizophrenia.

Publication ,  Journal Article
Simons, JS; Davis, SW; Gilbert, SJ; Frith, CD; Burgess, PW
Published in: Neuroimage
August 15, 2006

Some of the symptoms of schizophrenia may reflect a difficulty discriminating between information that was perceived from the outside world and information that was imagined. This study used fMRI to examine the brain regions associated with this reality monitoring ability in healthy volunteers, who recollected whether information had previously been perceived or imagined, or whether information had been presented on the left or right of a monitor screen. Recent studies have suggested that schizophrenia may be associated particularly with dysfunction in medial anterior prefrontal cortex, thalamus, and cerebellum. In our data, activation in all three of these regions of interest was significantly greater during recollection of whether stimuli had been perceived or imagined versus recollection of stimulus position. In addition, reduced prefrontal activation was associated with the same misattribution error that has been observed in schizophrenia. These results indicate a possible link between the brain areas implicated in schizophrenia and the regions supporting the ability to discriminate between perceived and imagined information.

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Published In

Neuroimage

DOI

ISSN

1053-8119

Publication Date

August 15, 2006

Volume

32

Issue

2

Start / End Page

696 / 703

Location

United States

Related Subject Headings

  • Schizophrenia
  • Reference Values
  • Reality Testing
  • Reading
  • Prefrontal Cortex
  • Paired-Associate Learning
  • Orientation
  • Neurology & Neurosurgery
  • Nerve Net
  • Mental Recall
 

Citation

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Simons, J. S., Davis, S. W., Gilbert, S. J., Frith, C. D., & Burgess, P. W. (2006). Discriminating imagined from perceived information engages brain areas implicated in schizophrenia. Neuroimage, 32(2), 696–703. https://doi.org/10.1016/j.neuroimage.2006.04.209
Simons, Jon S., Simon W. Davis, Sam J. Gilbert, Chris D. Frith, and Paul W. Burgess. “Discriminating imagined from perceived information engages brain areas implicated in schizophrenia.Neuroimage 32, no. 2 (August 15, 2006): 696–703. https://doi.org/10.1016/j.neuroimage.2006.04.209.
Simons JS, Davis SW, Gilbert SJ, Frith CD, Burgess PW. Discriminating imagined from perceived information engages brain areas implicated in schizophrenia. Neuroimage. 2006 Aug 15;32(2):696–703.
Simons, Jon S., et al. “Discriminating imagined from perceived information engages brain areas implicated in schizophrenia.Neuroimage, vol. 32, no. 2, Aug. 2006, pp. 696–703. Pubmed, doi:10.1016/j.neuroimage.2006.04.209.
Simons JS, Davis SW, Gilbert SJ, Frith CD, Burgess PW. Discriminating imagined from perceived information engages brain areas implicated in schizophrenia. Neuroimage. 2006 Aug 15;32(2):696–703.
Journal cover image

Published In

Neuroimage

DOI

ISSN

1053-8119

Publication Date

August 15, 2006

Volume

32

Issue

2

Start / End Page

696 / 703

Location

United States

Related Subject Headings

  • Schizophrenia
  • Reference Values
  • Reality Testing
  • Reading
  • Prefrontal Cortex
  • Paired-Associate Learning
  • Orientation
  • Neurology & Neurosurgery
  • Nerve Net
  • Mental Recall