TGFΒ-induced transcription in cancer.


Journal Article (Review)

The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway.

Full Text

Cited Authors

  • Cantelli, G; Crosas-Molist, E; Georgouli, M; Sanz-Moreno, V

Published Date

  • February 2017

Published In

Volume / Issue

  • 42 /

Start / End Page

  • 60 - 69

PubMed ID

  • 27586372

Pubmed Central ID

  • 27586372

Electronic International Standard Serial Number (EISSN)

  • 1096-3650

International Standard Serial Number (ISSN)

  • 1044-579X

Digital Object Identifier (DOI)

  • 10.1016/j.semcancer.2016.08.009


  • eng