Orthogonal micro-organization of orientation and spatial frequency in primate primary visual cortex.


Journal Article

Orientation and spatial frequency tuning are highly salient properties of neurons in primary visual cortex (V1). The combined organization of these particular tuning properties in the cortical space will strongly shape the V1 population response to different visual inputs, yet it is poorly understood. In this study, we used two-photon imaging in macaque monkey V1 to demonstrate the three-dimensional cell-by-cell layout of both spatial frequency and orientation tuning. We first found that spatial frequency tuning was organized into highly structured maps that remained consistent across the depth of layer II/III, similarly to orientation tuning. Next, we found that orientation and spatial frequency maps were intimately related at the fine spatial scale observed with two-photon imaging. Not only did the map gradients tend notably toward orthogonality, but they also co-varied negatively from cell to cell at the spatial scale of cortical columns.

Full Text

Cited Authors

  • Nauhaus, I; Nielsen, KJ; Disney, AA; Callaway, EM

Published Date

  • December 2012

Published In

Volume / Issue

  • 15 / 12

Start / End Page

  • 1683 - 1690

PubMed ID

  • 23143516

Pubmed Central ID

  • 23143516

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.3255


  • eng

Conference Location

  • United States