PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.

Published

Journal Article

Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encephalomyelitis (EAE). PD-1-/- and PD-L1-/- mice developed more severe EAE than wild type and PD-L2-/- mice. Consistent with this, PD-1-/- and PD-L1-/- cells produced elevated levels of the pro-inflammatory cytokines IFN-gamma, TNF, IL-6 and IL-17. These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE.

Full Text

Duke Authors

Cited Authors

  • Carter, LL; Leach, MW; Azoitei, ML; Cui, J; Pelker, JW; Jussif, J; Benoit, S; Ireland, G; Luxenberg, D; Askew, GR; Milarski, KL; Groves, C; Brown, T; Carito, BA; Percival, K; Carreno, BM; Collins, M; Marusic, S

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 182 / 1-2

Start / End Page

  • 124 - 134

PubMed ID

  • 17182110

Pubmed Central ID

  • 17182110

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2006.10.006

Language

  • eng