PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
Publication
, Journal Article
Carter, LL; Leach, MW; Azoitei, ML; Cui, J; Pelker, JW; Jussif, J; Benoit, S; Ireland, G; Luxenberg, D; Askew, GR; Milarski, KL; Groves, C ...
Published in: J Neuroimmunol
January 2007
Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encephalomyelitis (EAE). PD-1-/- and PD-L1-/- mice developed more severe EAE than wild type and PD-L2-/- mice. Consistent with this, PD-1-/- and PD-L1-/- cells produced elevated levels of the pro-inflammatory cytokines IFN-gamma, TNF, IL-6 and IL-17. These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE.
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Published In
J Neuroimmunol
DOI
ISSN
0165-5728
Publication Date
January 2007
Volume
182
Issue
1-2
Start / End Page
124 / 134
Location
Netherlands
Related Subject Headings
- Tumor Necrosis Factor-alpha
- T-Lymphocytes
- Severity of Illness Index
- Programmed Cell Death 1 Receptor
- Programmed Cell Death 1 Ligand 2 Protein
- Peptides
- Peptide Fragments
- Neurology & Neurosurgery
- Myelin-Oligodendrocyte Glycoprotein
- Mice, Transgenic
Citation
APA
Chicago
ICMJE
MLA
NLM
Carter, L. L., Leach, M. W., Azoitei, M. L., Cui, J., Pelker, J. W., Jussif, J., … Marusic, S. (2007). PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol, 182(1–2), 124–134. https://doi.org/10.1016/j.jneuroim.2006.10.006
Carter, Laura L., Michael W. Leach, Mihai L. Azoitei, Junqing Cui, Jeffrey W. Pelker, Jason Jussif, Steve Benoit, et al. “PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.” J Neuroimmunol 182, no. 1–2 (January 2007): 124–34. https://doi.org/10.1016/j.jneuroim.2006.10.006.
Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, et al. PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Jan;182(1–2):124–34.
Carter, Laura L., et al. “PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.” J Neuroimmunol, vol. 182, no. 1–2, Jan. 2007, pp. 124–34. Pubmed, doi:10.1016/j.jneuroim.2006.10.006.
Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, Benoit S, Ireland G, Luxenberg D, Askew GR, Milarski KL, Groves C, Brown T, Carito BA, Percival K, Carreno BM, Collins M, Marusic S. PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Jan;182(1–2):124–134.
Published In
J Neuroimmunol
DOI
ISSN
0165-5728
Publication Date
January 2007
Volume
182
Issue
1-2
Start / End Page
124 / 134
Location
Netherlands
Related Subject Headings
- Tumor Necrosis Factor-alpha
- T-Lymphocytes
- Severity of Illness Index
- Programmed Cell Death 1 Receptor
- Programmed Cell Death 1 Ligand 2 Protein
- Peptides
- Peptide Fragments
- Neurology & Neurosurgery
- Myelin-Oligodendrocyte Glycoprotein
- Mice, Transgenic