Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme.

Published

Journal Article

Glioblastoma multiforme is an aggressive malignant brain tumor. The monoclonal antibody, bevacizumab, is active in recurrent disease via inhibition of angiogenesis. Proteinuria and renal thrombotic microangiopathy are known complications. We report a case of a patient developing acute renal failure with biopsy-proven interstitial nephritis while receiving bevacizumab for recurrent disease. The patient was otherwise well with a history of controlled hypertension. Renal function improved with discontinuation of bevacizumab and the administration of corticosteroid therapy.

Full Text

Duke Authors

Cited Authors

  • Lomax, AJ; Hill, PA; Ashley, DM

Published Date

  • December 2013

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 365 - 368

PubMed ID

  • 23235917

Pubmed Central ID

  • 23235917

Electronic International Standard Serial Number (EISSN)

  • 1477-092X

International Standard Serial Number (ISSN)

  • 1078-1552

Digital Object Identifier (DOI)

  • 10.1177/1078155212466421

Language

  • eng