Deciphering the tête-à-tête between the microbiota and the immune system.

Journal Article (Journal Article;Review)

The past decade has witnessed an explosion in studies--both clinical and basic science--examining the relationship between the microbiota and human health, and it is now clear that the effects of commensal organisms are much broader than previously believed. Among the microbiota's major contributions to host physiology is regulation of the development and maintenance of the immune system. There are now a handful of examples of intestinal commensal bacteria with defined immunomodulatory properties, but our mechanistic understanding of how microbes influence the immune system is still in its infancy. Nevertheless, several themes have emerged that provide a framework for appreciating microbe-induced immunoregulation. In this Review, we discuss the current state of knowledge regarding the role of the intestinal microbiota in immunologic development, highlighting mechanistic principles that can guide future work.

Full Text

Duke Authors

Cited Authors

  • Surana, NK; Kasper, DL

Published Date

  • October 2014

Published In

Volume / Issue

  • 124 / 10

Start / End Page

  • 4197 - 4203

PubMed ID

  • 25036709

Pubmed Central ID

  • PMC4191050

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI72332


  • eng

Conference Location

  • United States