Gut immune maturation depends on colonization with a host-specific microbiota.

Published

Journal Article

Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to determine whether small intestinal immune maturation depends on a coevolved host-specific microbiota. Gut bacterial numbers and phylum abundance were similar in MMb and HMb mice, but bacterial species differed, especially the Firmicutes. HMb mouse intestines had low levels of CD4(+) and CD8(+) T cells, few proliferating T cells, few dendritic cells, and low antimicrobial peptide expression--all characteristics of GF mice. Rat microbiota also failed to fully expand intestinal T cell numbers in mice. Colonizing GF or HMb mice with mouse-segmented filamentous bacteria (SFB) partially restored T cell numbers, suggesting that SFB and other MMb organisms are required for full immune maturation in mice. Importantly, MMb conferred better protection against Salmonella infection than HMb. A host-specific microbiota appears to be critical for a healthy immune system.

Full Text

Duke Authors

Cited Authors

  • Chung, H; Pamp, SJ; Hill, JA; Surana, NK; Edelman, SM; Troy, EB; Reading, NC; Villablanca, EJ; Wang, S; Mora, JR; Umesaki, Y; Mathis, D; Benoist, C; Relman, DA; Kasper, DL

Published Date

  • June 2012

Published In

Volume / Issue

  • 149 / 7

Start / End Page

  • 1578 - 1593

PubMed ID

  • 22726443

Pubmed Central ID

  • 22726443

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2012.04.037

Language

  • eng