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The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.

Publication ,  Journal Article
Landstrom, AP; Ackerman, MJ
Published in: Clin Pharmacol Ther
October 2011

Although the etiologies of sudden cardiac death (SCD) are diverse, genetic mutations associated with cardiomyopathic and channelopathic diseases are major causes, and clinically available genetic tests offer the potential to identify at-risk family members, contribute to risk stratification, and guide therapeutic intervention. Recently, the first large-scale systematic studies exploring the background genetic "noise" rate of these tests have been conducted and offer guidance in interpreting positive genetic test results.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

October 2011

Volume

90

Issue

4

Start / End Page

496 / 499

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Humans
  • Health Behavior
  • Global Health
  • Cardiovascular Diseases
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Landstrom, A. P., & Ackerman, M. J. (2011). The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise. Clin Pharmacol Ther, 90(4), 496–499. https://doi.org/10.1038/clpt.2011.192
Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.Clin Pharmacol Ther 90, no. 4 (October 2011): 496–99. https://doi.org/10.1038/clpt.2011.192.
Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.Clin Pharmacol Ther, vol. 90, no. 4, Oct. 2011, pp. 496–99. Pubmed, doi:10.1038/clpt.2011.192.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

October 2011

Volume

90

Issue

4

Start / End Page

496 / 499

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Humans
  • Health Behavior
  • Global Health
  • Cardiovascular Diseases
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences