The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.
Publication
, Journal Article
Landstrom, AP; Ackerman, MJ
Published in: Clin Pharmacol Ther
October 2011
Although the etiologies of sudden cardiac death (SCD) are diverse, genetic mutations associated with cardiomyopathic and channelopathic diseases are major causes, and clinically available genetic tests offer the potential to identify at-risk family members, contribute to risk stratification, and guide therapeutic intervention. Recently, the first large-scale systematic studies exploring the background genetic "noise" rate of these tests have been conducted and offer guidance in interpreting positive genetic test results.
Duke Scholars
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
October 2011
Volume
90
Issue
4
Start / End Page
496 / 499
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Humans
- Health Behavior
- Global Health
- Cardiovascular Diseases
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Landstrom, A. P., & Ackerman, M. J. (2011). The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise. Clin Pharmacol Ther, 90(4), 496–499. https://doi.org/10.1038/clpt.2011.192
Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.” Clin Pharmacol Ther 90, no. 4 (October 2011): 496–99. https://doi.org/10.1038/clpt.2011.192.
Landstrom AP, Ackerman MJ. The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise. Clin Pharmacol Ther. 2011 Oct;90(4):496–9.
Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.” Clin Pharmacol Ther, vol. 90, no. 4, Oct. 2011, pp. 496–99. Pubmed, doi:10.1038/clpt.2011.192.
Landstrom AP, Ackerman MJ. The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise. Clin Pharmacol Ther. 2011 Oct;90(4):496–499.
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
October 2011
Volume
90
Issue
4
Start / End Page
496 / 499
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Humans
- Health Behavior
- Global Health
- Cardiovascular Diseases
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences