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HOXB13 and other high penetrant genes for prostate cancer.

Publication ,  Journal Article
Pilie, PG; Giri, VN; Cooney, KA
Published in: Asian J Androl
2016

Cancer initiation and progression is the result of an accumulation of mutations in key tumor suppressor genes, mismatch repair genes, or oncogenes, which impact cancer cell growth, death, and differentiation. Mutations occurring in cancer tissue are termed somatic; whereas, heritable mutations that may be passed onto subsequent generations occur in germline DNA. It is these germline mutations that can lead to cancer family syndromes whereby family members carrying a deleterious germline mutation have an increased susceptibility to certain cancer phenotypes. Common features of hereditary cancer syndromes include early age-of-onset, multiple affected generations, rare tumor types, and/or multiple primary malignancies. Approximately, 5%–10% of all common cancers, including prostate cancer, have a hereditary component and are attributable to highly penetrant germline mutations. Across all cancer types, known cancer susceptibility syndromes number >100; however, it is important to note that mutations in high-penetrance genes explain only a fraction of heritable cancers. Well-known examples of hereditary cancer syndromes include Lynch (HNPCC), Cowden (PHTS), Li-Fraumeni, and Hereditary Breast and Ovarian Cancer (HBOC) syndromes, which are attributable to mutations in mismatch repair genes, PTEN, p53, and BRCA1/2, respectively.

Duke Scholars

Published In

Asian J Androl

DOI

EISSN

1745-7262

Publication Date

2016

Volume

18

Issue

4

Start / End Page

530 / 532

Location

China

Related Subject Headings

  • Prostatic Neoplasms
  • Obstetrics & Reproductive Medicine
  • Male
  • Humans
  • Homeodomain Proteins
  • Genotype
  • Genetic Predisposition to Disease
  • 3215 Reproductive medicine
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pilie, P. G., Giri, V. N., & Cooney, K. A. (2016). HOXB13 and other high penetrant genes for prostate cancer. Asian J Androl, 18(4), 530–532. https://doi.org/10.4103/1008-682X.175785
Pilie, Patrick G., Veda N. Giri, and Kathleen A. Cooney. “HOXB13 and other high penetrant genes for prostate cancer.Asian J Androl 18, no. 4 (2016): 530–32. https://doi.org/10.4103/1008-682X.175785.
Pilie PG, Giri VN, Cooney KA. HOXB13 and other high penetrant genes for prostate cancer. Asian J Androl. 2016;18(4):530–2.
Pilie, Patrick G., et al. “HOXB13 and other high penetrant genes for prostate cancer.Asian J Androl, vol. 18, no. 4, 2016, pp. 530–32. Pubmed, doi:10.4103/1008-682X.175785.
Pilie PG, Giri VN, Cooney KA. HOXB13 and other high penetrant genes for prostate cancer. Asian J Androl. 2016;18(4):530–532.
Journal cover image

Published In

Asian J Androl

DOI

EISSN

1745-7262

Publication Date

2016

Volume

18

Issue

4

Start / End Page

530 / 532

Location

China

Related Subject Headings

  • Prostatic Neoplasms
  • Obstetrics & Reproductive Medicine
  • Male
  • Humans
  • Homeodomain Proteins
  • Genotype
  • Genetic Predisposition to Disease
  • 3215 Reproductive medicine
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine