Prostate cancer in young men: an important clinical entity.

Published

Journal Article (Review)

Prostate cancer is considered a disease of older men (aged >65 years), but today over 10% of new diagnoses in the USA occur in young men aged ≤55 years. Early-onset prostate cancer, that is prostate cancer diagnosed at age ≤55 years, differs from prostate cancer diagnosed at an older age in several ways. Firstly, among men with high-grade and advanced-stage prostate cancer, those diagnosed at a young age have a higher cause-specific mortality than men diagnosed at an older age, except those over age 80 years. This finding suggests that important biological differences exist between early-onset prostate cancer and late-onset disease. Secondly, early-onset prostate cancer has a strong genetic component, which indicates that young men with prostate cancer could benefit from evaluation of genetic risk. Furthermore, although the majority of men with early-onset prostate cancer are diagnosed with low-risk disease, the extended life expectancy of these patients exposes them to long-term effects of treatment-related morbidities and to long-term risk of disease progression leading to death from prostate cancer. For these reasons, patients with early-onset prostate cancer pose unique challenges, as well as opportunities, for both research and clinical communities. Current data suggest that early-onset prostate cancer is a distinct phenotype-from both an aetiological and clinical perspective-that deserves further attention.

Full Text

Duke Authors

Cited Authors

  • Salinas, CA; Tsodikov, A; Ishak-Howard, M; Cooney, KA

Published Date

  • June 2014

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 317 - 323

PubMed ID

  • 24818853

Pubmed Central ID

  • 24818853

Electronic International Standard Serial Number (EISSN)

  • 1759-4820

International Standard Serial Number (ISSN)

  • 1759-4812

Digital Object Identifier (DOI)

  • 10.1038/nrurol.2014.91

Language

  • eng