Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.

Journal Article (Journal Article)

Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1) gene have recently been implicated as potential prostate cancer susceptibility factors. However, existing studies are limited by the referral-based nature of samples and a paucity of African-American participants. In this context, we evaluated the association of germ-line mutations and common MSR1 sequence variants with prostate cancer risk in a case control study of a community-based sample of 134 African-American men with prostate cancer and 340 unaffected controls. In our sample, the rare Asp174Tyr missense change was identified nearly twice as frequently in men with prostate cancer (6.8%) compared with unaffected controls (3.6%; P = 0.14). Moreover, significantly different allele frequencies between cases and controls were observed for one of the sequence variants, IVS5-59 (P = 0.02). Taken together, our results provide some additional support for the hypothesis that selected, rare MSR1 mutations are associated with increased prostate cancer susceptibility among African-American men.

Full Text

Duke Authors

Cited Authors

  • Miller, DC; Zheng, SL; Dunn, RL; Sarma, AV; Montie, JE; Lange, EM; Meyers, DA; Xu, J; Cooney, KA

Published Date

  • July 1, 2003

Published In

Volume / Issue

  • 63 / 13

Start / End Page

  • 3486 - 3489

PubMed ID

  • 12839931

International Standard Serial Number (ISSN)

  • 0008-5472


  • eng

Conference Location

  • United States