Skip to main content

Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.

Publication ,  Journal Article
Miller, DC; Zheng, SL; Dunn, RL; Sarma, AV; Montie, JE; Lange, EM; Meyers, DA; Xu, J; Cooney, KA
Published in: Cancer Res
July 1, 2003

Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1) gene have recently been implicated as potential prostate cancer susceptibility factors. However, existing studies are limited by the referral-based nature of samples and a paucity of African-American participants. In this context, we evaluated the association of germ-line mutations and common MSR1 sequence variants with prostate cancer risk in a case control study of a community-based sample of 134 African-American men with prostate cancer and 340 unaffected controls. In our sample, the rare Asp174Tyr missense change was identified nearly twice as frequently in men with prostate cancer (6.8%) compared with unaffected controls (3.6%; P = 0.14). Moreover, significantly different allele frequencies between cases and controls were observed for one of the sequence variants, IVS5-59 (P = 0.02). Taken together, our results provide some additional support for the hypothesis that selected, rare MSR1 mutations are associated with increased prostate cancer susceptibility among African-American men.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1, 2003

Volume

63

Issue

13

Start / End Page

3486 / 3489

Location

United States

Related Subject Headings

  • United States
  • Scavenger Receptors, Class A
  • Risk Factors
  • Reference Values
  • Receptors, Scavenger
  • Receptors, Immunologic
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Michigan
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Miller, D. C., Zheng, S. L., Dunn, R. L., Sarma, A. V., Montie, J. E., Lange, E. M., … Cooney, K. A. (2003). Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. Cancer Res, 63(13), 3486–3489.
Miller, David C., S Lilly Zheng, Rodney L. Dunn, Aruna V. Sarma, James E. Montie, Ethan M. Lange, Deborah A. Meyers, Jianfeng Xu, and Kathleen A. Cooney. “Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.Cancer Res 63, no. 13 (July 1, 2003): 3486–89.
Miller DC, Zheng SL, Dunn RL, Sarma AV, Montie JE, Lange EM, et al. Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. Cancer Res. 2003 Jul 1;63(13):3486–9.
Miller, David C., et al. “Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.Cancer Res, vol. 63, no. 13, July 2003, pp. 3486–89.
Miller DC, Zheng SL, Dunn RL, Sarma AV, Montie JE, Lange EM, Meyers DA, Xu J, Cooney KA. Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. Cancer Res. 2003 Jul 1;63(13):3486–3489.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1, 2003

Volume

63

Issue

13

Start / End Page

3486 / 3489

Location

United States

Related Subject Headings

  • United States
  • Scavenger Receptors, Class A
  • Risk Factors
  • Reference Values
  • Receptors, Scavenger
  • Receptors, Immunologic
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Michigan
  • Male