Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men.

Journal Article (Journal Article)

BACKGROUND: Previous studies have found associations between mitochondrial DNA (mtDNA) mutations and several cancer types. Recently, we found that mutations in the mtDNA gene cytochrome c oxidase subunit 1 (COI) were both linked to and associated with prostate cancer (PCa) in Caucasian men. Here we examine the association between COI mutations and PCa in African American men. METHODS: The entire COI gene was directly sequenced in 132 PCa cases and 135 controls from the Flint Men's Health Study, a community-based sample of African American men with and without PCa. Associations between all variants and PCa were evaluated. RESULTS: We identified 102 COI single nucleotide polymorphisms (SNPs), including 15 missense variants. Overall, the presence of one or more COI missense variants was not significantly associated with PCa. Individually, two SNPs (T6221C and T7389C) were significantly associated with prostate cancer (P < 0.05) and in strong linkage disequilibrium with each other (r(2) > 0.6). CONCLUSIONS: Of the two significantly associated SNPs, one is a synonymous substitution and the other is part of the African-specific mitochondrial haplogroup (L). Additional research will be needed to determine the clinical relevance of these associations in African populations.

Full Text

Duke Authors

Cited Authors

  • Ray, AM; Zuhlke, KA; Levin, AM; Douglas, JA; Cooney, KA; Petros, JA

Published Date

  • June 15, 2009

Published In

Volume / Issue

  • 69 / 9

Start / End Page

  • 956 - 960

PubMed ID

  • 19267350

Pubmed Central ID

  • PMC2729404

Electronic International Standard Serial Number (EISSN)

  • 1097-0045

Digital Object Identifier (DOI)

  • 10.1002/pros.20943


  • eng

Conference Location

  • United States