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Hereditary prostate cancer as a feature of Lynch syndrome.

Publication ,  Journal Article
Bauer, CM; Ray, AM; Halstead-Nussloch, BA; Dekker, RG; Raymond, VM; Gruber, SB; Cooney, KA
Published in: Fam Cancer
March 2011

Lynch Syndrome is an autosomal dominant condition characterized by early onset colorectal cancer (CRC) and is associated with cancers of the gastrointestinal and reproductive tracts. Germline mutations in DNA mismatch repair (MMR) genes have been causally associated with cancers of Lynch Syndrome. We investigated the occurrence of prostate cancer (PCa) in families with a history of colorectal cancer to assess prostate cancer as a feature of the Lynch Syndrome spectrum. Family pedigrees containing at least one CRC case as well as those meeting guidelines for Lynch Syndrome were identified and tumors were requested from participants who underwent radical prostatectomy (RP). Selected families were analyzed for association with type of PCa and clinical characteristics of aggressive disease. Microsatellite Instability (MSI) analysis was preformed on available tumors and correlated to loss of expression in MMR genes by immunohistochemical (IHC) staining. 95 individuals were identified as members of potential Lynch Syndrome families who underwent RP and 35 tumors from 31 families were received for MSI analysis. Two tumors from two unrelated families with known MMR mutations were MSI-high and one additional case from a third family was MSI-low. The remainder of the prostate cancer cases demonstrated no evidence of MSI. PCa incidence in families enriched for hereditary PCa with a history of Lynch Syndrome cancers is not strongly suggestive of the presence of an MMR mutation. However prostate tumors in known MMR mutation carriers did display MSI and loss of gene expression suggesting that PCa may arise in Lynch Syndrome due to defective DNA mismatch repair.

Duke Scholars

Published In

Fam Cancer

DOI

EISSN

1573-7292

Publication Date

March 2011

Volume

10

Issue

1

Start / End Page

37 / 42

Location

Netherlands

Related Subject Headings

  • Prostatic Neoplasms
  • Prognosis
  • Polymerase Chain Reaction
  • Pedigree
  • Oncology & Carcinogenesis
  • Mutation
  • MutS Homolog 2 Protein
  • Middle Aged
  • Microsatellite Instability
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bauer, C. M., Ray, A. M., Halstead-Nussloch, B. A., Dekker, R. G., Raymond, V. M., Gruber, S. B., & Cooney, K. A. (2011). Hereditary prostate cancer as a feature of Lynch syndrome. Fam Cancer, 10(1), 37–42. https://doi.org/10.1007/s10689-010-9388-8
Bauer, Christina M., Anna M. Ray, Bronwen A. Halstead-Nussloch, Robert G. Dekker, Victoria M. Raymond, Stephen B. Gruber, and Kathleen A. Cooney. “Hereditary prostate cancer as a feature of Lynch syndrome.Fam Cancer 10, no. 1 (March 2011): 37–42. https://doi.org/10.1007/s10689-010-9388-8.
Bauer CM, Ray AM, Halstead-Nussloch BA, Dekker RG, Raymond VM, Gruber SB, et al. Hereditary prostate cancer as a feature of Lynch syndrome. Fam Cancer. 2011 Mar;10(1):37–42.
Bauer, Christina M., et al. “Hereditary prostate cancer as a feature of Lynch syndrome.Fam Cancer, vol. 10, no. 1, Mar. 2011, pp. 37–42. Pubmed, doi:10.1007/s10689-010-9388-8.
Bauer CM, Ray AM, Halstead-Nussloch BA, Dekker RG, Raymond VM, Gruber SB, Cooney KA. Hereditary prostate cancer as a feature of Lynch syndrome. Fam Cancer. 2011 Mar;10(1):37–42.
Journal cover image

Published In

Fam Cancer

DOI

EISSN

1573-7292

Publication Date

March 2011

Volume

10

Issue

1

Start / End Page

37 / 42

Location

Netherlands

Related Subject Headings

  • Prostatic Neoplasms
  • Prognosis
  • Polymerase Chain Reaction
  • Pedigree
  • Oncology & Carcinogenesis
  • Mutation
  • MutS Homolog 2 Protein
  • Middle Aged
  • Microsatellite Instability
  • Male