Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci.

Journal Article (Journal Article)

African American men have the highest incidence of prostate cancer in the world. Despite this statistic, linkage studies designed to localise prostate cancer susceptibility alleles have included primarily men of Caucasian descent. In this report, we performed a linkage analysis using 33 African American prostate cancer families from two independent research groups. In total, 126 individuals (including 89 men with prostate cancer) were genotyped using markers that map to five prostate cancer susceptibility loci, namely HPC1 at 1q24-25, PCAP at 1q42.2-43, CAPB at 1p36, HPC20 on chromosome 20, and HPCX at Xq27-28. Multipoint mode-of-inheritance-free linkage analyses were performed using the GENEHUNTER software. Some evidence of prostate cancer was detected to HPC1 using all families with a maximum NPL Z score of 1.12 near marker D1S413 (P=0.13). Increased evidence of linkage was observed in the 24 families with prostate cancer diagnosis prior to age 65 years and in the 20 families with male-to-male transmission. Some evidence of prostate cancer linkage was also detected at markers mapping to PCAP, HPC20, and HPCX. Continued collection and analysis of African American prostate cancer families will lead to an improved understanding of inherited susceptibility in this high-risk group.

Full Text

Duke Authors

Cited Authors

  • Brown, WM; Lange, EM; Chen, H; Zheng, SL; Chang, B; Wiley, KE; Isaacs, SD; Walsh, PC; Isaacs, WB; Xu, J; Cooney, KA

Published Date

  • January 26, 2004

Published In

Volume / Issue

  • 90 / 2

Start / End Page

  • 510 - 514

PubMed ID

  • 14735201

Pubmed Central ID

  • PMC2410149

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6601417


  • eng

Conference Location

  • England