Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.


Journal Article

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

Full Text

Duke Authors

Cited Authors

  • Eeles, RA; Kote-Jarai, Z; Al Olama, AA; Giles, GG; Guy, M; Severi, G; Muir, K; Hopper, JL; Henderson, BE; Haiman, CA; Schleutker, J; Hamdy, FC; Neal, DE; Donovan, JL; Stanford, JL; Ostrander, EA; Ingles, SA; John, EM; Thibodeau, SN; Schaid, D; Park, JY; Spurdle, A; Clements, J; Dickinson, JL; Maier, C; Vogel, W; Dörk, T; Rebbeck, TR; Cooney, KA; Cannon-Albright, L; Chappuis, PO; Hutter, P; Zeegers, M; Kaneva, R; Zhang, H-W; Lu, Y-J; Foulkes, WD; English, DR; Leongamornlert, DA; Tymrakiewicz, M; Morrison, J; Ardern-Jones, AT; Hall, AL; O'Brien, LT; Wilkinson, RA; Saunders, EJ; Page, EC; Sawyer, EJ; Edwards, SM; Dearnaley, DP; Horwich, A; Huddart, RA; Khoo, VS; Parker, CC; Van As, N; Woodhouse, CJ; Thompson, A; Christmas, T; Ogden, C; Cooper, CS; Southey, MC; Lophatananon, A; Liu, J-F; Kolonel, LN; Le Marchand, L; Wahlfors, T; Tammela, TL; Auvinen, A; Lewis, SJ; Cox, A; FitzGerald, LM; Koopmeiners, JS; Karyadi, DM; Kwon, EM; Stern, MC; Corral, R; Joshi, AD; Shahabi, A; McDonnell, SK; Sellers, TA; Pow-Sang, J; Chambers, S; Aitken, J; Gardiner, RAF; Batra, J; Kedda, MA; Lose, F; Polanowski, A; Patterson, B; Serth, J; Meyer, A; Luedeke, M; Stefflova, K; Ray, AM; Lange, EM; Farnham, J; Khan, H; Slavov, C; Mitkova, A; Cao, G; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, ; UK ProtecT Study Collaborators, ; PRACTICAL Consortium, ; Easton, DF

Published Date

  • October 2009

Published In

Volume / Issue

  • 41 / 10

Start / End Page

  • 1116 - 1121

PubMed ID

  • 19767753

Pubmed Central ID

  • 19767753

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.450


  • eng

Conference Location

  • United States