Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).
Eeles, RA; Kote-Jarai, Z; Al Olama, AA; Giles, GG; Guy, M; Severi, G; Muir, K; Hopper, JL; Henderson, BE; Haiman, CA; Schleutker, J; Hamdy, FC; Neal, DE; Donovan, JL; Stanford, JL; Ostrander, EA; Ingles, SA; John, EM; Thibodeau, SN; Schaid, D; Park, JY; Spurdle, A; Clements, J; Dickinson, JL; Maier, C; Vogel, W; Dörk, T; Rebbeck, TR; Cooney, KA; Cannon-Albright, L; Chappuis, PO; Hutter, P; Zeegers, M; Kaneva, R; Zhang, H-W; Lu, Y-J; Foulkes, WD; English, DR; Leongamornlert, DA; Tymrakiewicz, M; Morrison, J; Ardern-Jones, AT; Hall, AL; O'Brien, LT; Wilkinson, RA; Saunders, EJ; Page, EC; Sawyer, EJ; Edwards, SM; Dearnaley, DP; Horwich, A; Huddart, RA; Khoo, VS; Parker, CC; Van As, N; Woodhouse, CJ; Thompson, A; Christmas, T; Ogden, C; Cooper, CS; Southey, MC; Lophatananon, A; Liu, J-F; Kolonel, LN; Le Marchand, L; Wahlfors, T; Tammela, TL; Auvinen, A; Lewis, SJ; Cox, A; FitzGerald, LM; Koopmeiners, JS; Karyadi, DM; Kwon, EM; Stern, MC; Corral, R; Joshi, AD; Shahabi, A; McDonnell, SK; Sellers, TA; Pow-Sang, J; Chambers, S; Aitken, J; Gardiner, RAF; Batra, J; Kedda, MA; Lose, F; Polanowski, A; Patterson, B; Serth, J; Meyer, A; Luedeke, M; Stefflova, K; Ray, AM; Lange, EM; Farnham, J; Khan, H; Slavov, C; Mitkova, A; Cao, G; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, ; UK ProtecT Study Collaborators, ; PRACTICAL Consortium, ; Easton, DF
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