Skip to main content

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

Publication ,  Journal Article
Haiman, CA; Chen, GK; Blot, WJ; Strom, SS; Berndt, SI; Kittles, RA; Rybicki, BA; Isaacs, WB; Ingles, SA; Stanford, JL; Diver, WR; Witte, JS ...
Published in: Nat Genet
June 2011

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

June 2011

Volume

43

Issue

6

Start / End Page

570 / 573

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Developmental Biology
  • Chromosomes, Human, Pair 17
  • Black or African American
  • 3105 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haiman, C. A., Chen, G. K., Blot, W. J., Strom, S. S., Berndt, S. I., Kittles, R. A., … Henderson, B. E. (2011). Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet, 43(6), 570–573. https://doi.org/10.1038/ng.839
Haiman, Christopher A., Gary K. Chen, William J. Blot, Sara S. Strom, Sonja I. Berndt, Rick A. Kittles, Benjamin A. Rybicki, et al. “Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.Nat Genet 43, no. 6 (June 2011): 570–73. https://doi.org/10.1038/ng.839.
Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, et al. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet. 2011 Jun;43(6):570–3.
Haiman, Christopher A., et al. “Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.Nat Genet, vol. 43, no. 6, June 2011, pp. 570–73. Pubmed, doi:10.1038/ng.839.
Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, Cooney KA, Xu J, Kibel AS, Hu JJ, John EM, Gueye SM, Watya S, Signorello LB, Hayes RB, Wang Z, Yeboah E, Tettey Y, Cai Q, Kolb S, Ostrander EA, Zeigler-Johnson C, Yamamura Y, Neslund-Dudas C, Haslag-Minoff J, Wu W, Thomas V, Allen GO, Murphy A, Chang B-L, Zheng SL, Leske MC, Wu S-Y, Ray AM, Hennis AJM, Thun MJ, Carpten J, Casey G, Carter EN, Duarte ER, Xia LY, Sheng X, Wan P, Pooler LC, Cheng I, Monroe KR, Schumacher F, Le Marchand L, Kolonel LN, Chanock SJ, Van Den Berg D, Stram DO, Henderson BE. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet. 2011 Jun;43(6):570–573.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

June 2011

Volume

43

Issue

6

Start / End Page

570 / 573

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Developmental Biology
  • Chromosomes, Human, Pair 17
  • Black or African American
  • 3105 Genetics