Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.
Haiman, CA; Chen, GK; Blot, WJ; Strom, SS; Berndt, SI; Kittles, RA; Rybicki, BA; Isaacs, WB; Ingles, SA; Stanford, JL; Diver, WR; Witte, JS; Hsing, AW; Nemesure, B; Rebbeck, TR; Cooney, KA; Xu, J; Kibel, AS; Hu, JJ; John, EM; Gueye, SM; Watya, S; Signorello, LB; Hayes, RB; Wang, Z; Yeboah, E; Tettey, Y; Cai, Q; Kolb, S; Ostrander, EA; Zeigler-Johnson, C; Yamamura, Y; Neslund-Dudas, C; Haslag-Minoff, J; Wu, W; Thomas, V; Allen, GO; Murphy, A; Chang, B-L; Zheng, SL; Leske, MC; Wu, S-Y; Ray, AM; Hennis, AJM; Thun, MJ; Carpten, J; Casey, G; Carter, EN; Duarte, ER; Xia, LY; Sheng, X; Wan, P; Pooler, LC; Cheng, I; Monroe, KR; Schumacher, F; Le Marchand, L; Kolonel, LN; Chanock, SJ; Van Den Berg, D; Stram, DO; Henderson, BE
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