Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.


Journal Article

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Full Text

Duke Authors

Cited Authors

  • Haiman, CA; Chen, GK; Blot, WJ; Strom, SS; Berndt, SI; Kittles, RA; Rybicki, BA; Isaacs, WB; Ingles, SA; Stanford, JL; Diver, WR; Witte, JS; Hsing, AW; Nemesure, B; Rebbeck, TR; Cooney, KA; Xu, J; Kibel, AS; Hu, JJ; John, EM; Gueye, SM; Watya, S; Signorello, LB; Hayes, RB; Wang, Z; Yeboah, E; Tettey, Y; Cai, Q; Kolb, S; Ostrander, EA; Zeigler-Johnson, C; Yamamura, Y; Neslund-Dudas, C; Haslag-Minoff, J; Wu, W; Thomas, V; Allen, GO; Murphy, A; Chang, B-L; Zheng, SL; Leske, MC; Wu, S-Y; Ray, AM; Hennis, AJM; Thun, MJ; Carpten, J; Casey, G; Carter, EN; Duarte, ER; Xia, LY; Sheng, X; Wan, P; Pooler, LC; Cheng, I; Monroe, KR; Schumacher, F; Le Marchand, L; Kolonel, LN; Chanock, SJ; Van Den Berg, D; Stram, DO; Henderson, BE

Published Date

  • June 2011

Published In

Volume / Issue

  • 43 / 6

Start / End Page

  • 570 - 573

PubMed ID

  • 21602798

Pubmed Central ID

  • 21602798

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.839


  • eng

Conference Location

  • United States