Analysis of the gene coding for the BRCA2-interacting protein PALB2 in hereditary prostate cancer.

Published

Journal Article

The genetic basis of susceptibility to prostate cancer (PRCA) remains elusive. Mutations in BRCA2 have been associated with increased prostate cancer risk and account for around 2% of young onset (<56 years) prostate cancer cases. PALB2 is a recently identified breast cancer susceptibility gene whose protein is closely associated with BRCA2 and is essential for BRCA2 anchorage to nuclear structures. This functional relationship made PALB2 a candidate PRCA susceptibility gene.We sequenced PALB2 in probands from 95 PRCA families, 77 of which had two or more cases of early onset PRCA (age at diagnosis <55 years), and the remaining 18 had one case of early onset PRCA and five or more total cases of PRCA.Two previously unreported variants, K18R and V925L were identified, neither of which is in a known PALB2 functional domain and both of which are unlikely to be pathogenic. No truncating mutations were identified.These results indicate that deleterious PALB2 mutations are unlikely to play a significant role in hereditary prostate cancer.

Full Text

Duke Authors

Cited Authors

  • Tischkowitz, M; Sabbaghian, N; Ray, AM; Lange, EM; Foulkes, WD; Cooney, KA

Published Date

  • May 2008

Published In

Volume / Issue

  • 68 / 6

Start / End Page

  • 675 - 678

PubMed ID

  • 18288683

Pubmed Central ID

  • 18288683

Electronic International Standard Serial Number (EISSN)

  • 1097-0045

International Standard Serial Number (ISSN)

  • 0270-4137

Digital Object Identifier (DOI)

  • 10.1002/pros.20729

Language

  • eng